High Intensity Interval Training, known as HIIT, is a useful strategy for promoting longevity and combating the processes of chronic inflammation. The latter, characterised by a build-up of protein such as tumour necrosis factor (TNF) and interleukin-6 (IL-6), are closely linked to the onset of cardiovascular diseases, type 2 diabetes and cognitive decline. HIIT stands out thanks to the unusual way in which it alternates brief periods of intense physical effort with phases of active recovery, stimulating the body into favourable metabolic and immune responses. Recent scientific studies, starting with the one published in Sports Medicine in May 2023, have demonstrated that this type of training not only significantly reduces levels of pro-inflammatory cytokines (substances that promote inflammation and are linked to obesity), but also promotes the production of anti-inflammatory molecules such as myokines. These effects not only improve quality of life, but also delay degenerative processes linked to cellular and systemic ageing, contributing to lengthening the healthspan, or the period of healthy life.